Correlation of dopamine transporter imaging with parkinsonian motor handicap: How close is it?
Identifieur interne : 004144 ( Main/Exploration ); précédent : 004143; suivant : 004145Correlation of dopamine transporter imaging with parkinsonian motor handicap: How close is it?
Auteurs : Walter Pirker [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-10.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Activities of Daily Living (classification), Aged, Biological transport, Brain (radionuclide imaging), Cocaine (analogs & derivatives), Cocaine (diagnostic use), Corpus Striatum (radionuclide imaging), Diagnosis, Differential, Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (diagnostic use), Disability, Dominance, Cerebral (physiology), Dopamine, Dopamine Plasma Membrane Transport Proteins, Evolution, Female, Fluorine Radioisotopes (diagnostic use), Human, Humans, Iodine Radioisotopes (diagnostic use), Male, Membrane Glycoproteins, Membrane Transport Proteins (analysis), Middle Aged, Motor handicap, Nerve Tissue Proteins, Neural Pathways (radionuclide imaging), Neurologic Examination, PET, Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease, Positron emission tomography, Psychometrics, SPECT, Sensitivity and Specificity, Single photon emission tomography, Substantia Nigra (radionuclide imaging), Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon, UPDRS, dopamine transporter, motor handicap.
- MESH :
- chemical , analogs & derivatives : Cocaine, Dihydroxyphenylalanine.
- chemical , analysis : Membrane Transport Proteins.
- classification : Activities of Daily Living.
- chemical , diagnostic use : Cocaine, Dihydroxyphenylalanine, Fluorine Radioisotopes, Iodine Radioisotopes.
- physiology : Dominance, Cerebral.
- radionuclide imaging : Brain, Corpus Striatum, Neural Pathways, Parkinson Disease, Substantia Nigra.
- Aged, Diagnosis, Differential, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Male, Membrane Glycoproteins, Middle Aged, Nerve Tissue Proteins, Neurologic Examination, Sensitivity and Specificity, Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon.
Abstract
During the past decade, dopamine transporter (DAT) imaging with single photon emission computerized tomography (SPECT) or positron emission tomography (PET) has evolved as an objective in vivo marker of nigrostriatal neuron loss in Parkinson's disease (PD). We investigate the relationship between striatal DAT binding, measured with [123I]β‐CIT SPECT, and parkinsonian motor handicap in a sample of 59 PD patients with minimal to severe disability, and review published cross‐sectional studies on the correlation between DAT imaging and motor symptoms in PD. Earlier studies as well as the present results show a good correlation between overall striatal DAT binding and global measures of disease severity such as the Hoehn and Yahr scale, the total score on the Unified Parkinson's Disease Rating Scale (UPDRS), and UPDRS activities of daily living, with a progressive decline of DAT binding with increasing disability. A number of studies found a significant inverse correlation of striatal DAT binding with UPDRS motor score. Bradykinesia, posture, gait, and other midline symptoms, such as speech and facial expression, compared with rigidity, seem to be more closely related to striatal DAT binding. By contrast, neither the severity of parkinsonian rest nor of action tremor is related to the degree of dopaminergic denervation as measured by DAT imaging. Motor symptoms in the clinically less affected body side show a closer correlation with striatal DAT binding than do symptoms occurring in the dominantly affected body side. The correlation of putamen and caudate DAT binding with parkinsonian motor handicap seems to be similar. Although there have been limited comparative studies applying [18F]fluorodopa PET and DAT imaging in the same group of PD patients, available data suggest that putamen [18F]fluorodopa uptake, when compared with striatal DAT binding, may be more closely related to parkinsonian motor handicap. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10579
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000391
- to stream Istex, to step Curation: 000391
- to stream Istex, to step Checkpoint: 002A74
- to stream PubMed, to step Corpus: 003678
- to stream PubMed, to step Curation: 003678
- to stream PubMed, to step Checkpoint: 003830
- to stream Ncbi, to step Merge: 000B86
- to stream Ncbi, to step Curation: 000B86
- to stream Ncbi, to step Checkpoint: 000B86
- to stream Main, to step Merge: 005D67
- to stream PascalFrancis, to step Corpus: 002348
- to stream PascalFrancis, to step Curation: 000973
- to stream PascalFrancis, to step Checkpoint: 002504
- to stream Main, to step Merge: 006050
- to stream Main, to step Curation: 004144
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Correlation of dopamine transporter imaging with parkinsonian motor handicap: How close is it?</title><author><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EE5E852D2FAD10ECDAA841B72FF380AB478A3006</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1002/mds.10579</idno><idno type="url">https://api.istex.fr/document/EE5E852D2FAD10ECDAA841B72FF380AB478A3006/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000391</idno><idno type="wicri:Area/Istex/Curation">000391</idno><idno type="wicri:Area/Istex/Checkpoint">002A74</idno><idno type="wicri:doubleKey">0885-3185:2003:Pirker W:correlation:of:dopamine</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:14531046</idno><idno type="wicri:Area/PubMed/Corpus">003678</idno><idno type="wicri:Area/PubMed/Curation">003678</idno><idno type="wicri:Area/PubMed/Checkpoint">003830</idno><idno type="wicri:Area/Ncbi/Merge">000B86</idno><idno type="wicri:Area/Ncbi/Curation">000B86</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B86</idno><idno type="wicri:doubleKey">0885-3185:2003:Pirker W:correlation:of:dopamine</idno><idno type="wicri:Area/Main/Merge">005D67</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:04-0115371</idno><idno type="wicri:Area/PascalFrancis/Corpus">002348</idno><idno type="wicri:Area/PascalFrancis/Curation">000973</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002504</idno><idno type="wicri:doubleKey">0885-3185:2003:Pirker W:correlation:of:dopamine</idno><idno type="wicri:Area/Main/Merge">006050</idno><idno type="wicri:Area/Main/Curation">004144</idno><idno type="wicri:Area/Main/Exploration">004144</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Correlation of dopamine transporter imaging with parkinsonian motor handicap: How close is it?</title><author><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-10">2003-10</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">S7</biblScope><biblScope unit="supplement">7</biblScope><biblScope unit="page" from="S43">S43</biblScope><biblScope unit="page" to="S51">S51</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">EE5E852D2FAD10ECDAA841B72FF380AB478A3006</idno><idno type="DOI">10.1002/mds.10579</idno><idno type="ArticleID">MDS10579</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living (classification)</term><term>Aged</term><term>Biological transport</term><term>Brain (radionuclide imaging)</term><term>Cocaine (analogs & derivatives)</term><term>Cocaine (diagnostic use)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Diagnosis, Differential</term><term>Dihydroxyphenylalanine (analogs & derivatives)</term><term>Dihydroxyphenylalanine (diagnostic use)</term><term>Disability</term><term>Dominance, Cerebral (physiology)</term><term>Dopamine</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Evolution</term><term>Female</term><term>Fluorine Radioisotopes (diagnostic use)</term><term>Human</term><term>Humans</term><term>Iodine Radioisotopes (diagnostic use)</term><term>Male</term><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins (analysis)</term><term>Middle Aged</term><term>Motor handicap</term><term>Nerve Tissue Proteins</term><term>Neural Pathways (radionuclide imaging)</term><term>Neurologic Examination</term><term>PET</term><term>Parkinson Disease (radionuclide imaging)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Positron emission tomography</term><term>Psychometrics</term><term>SPECT</term><term>Sensitivity and Specificity</term><term>Single photon emission tomography</term><term>Substantia Nigra (radionuclide imaging)</term><term>Tomography, Emission-Computed</term><term>Tomography, Emission-Computed, Single-Photon</term><term>UPDRS</term><term>dopamine transporter</term><term>motor handicap</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Cocaine</term><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Activities of Daily Living</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Cocaine</term><term>Dihydroxyphenylalanine</term><term>Fluorine Radioisotopes</term><term>Iodine Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term><term>Corpus Striatum</term><term>Neural Pathways</term><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Diagnosis, Differential</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Humans</term><term>Male</term><term>Membrane Glycoproteins</term><term>Middle Aged</term><term>Nerve Tissue Proteins</term><term>Neurologic Examination</term><term>Sensitivity and Specificity</term><term>Tomography, Emission-Computed</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dopamine</term><term>Evolution</term><term>Handicap moteur</term><term>Homme</term><term>Incapacité</term><term>Parkinson maladie</term><term>Psychométrie</term><term>Tomographie émission positon</term><term>Tomoscintigraphie émission monophotonique</term><term>Transport biologique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During the past decade, dopamine transporter (DAT) imaging with single photon emission computerized tomography (SPECT) or positron emission tomography (PET) has evolved as an objective in vivo marker of nigrostriatal neuron loss in Parkinson's disease (PD). We investigate the relationship between striatal DAT binding, measured with [123I]β‐CIT SPECT, and parkinsonian motor handicap in a sample of 59 PD patients with minimal to severe disability, and review published cross‐sectional studies on the correlation between DAT imaging and motor symptoms in PD. Earlier studies as well as the present results show a good correlation between overall striatal DAT binding and global measures of disease severity such as the Hoehn and Yahr scale, the total score on the Unified Parkinson's Disease Rating Scale (UPDRS), and UPDRS activities of daily living, with a progressive decline of DAT binding with increasing disability. A number of studies found a significant inverse correlation of striatal DAT binding with UPDRS motor score. Bradykinesia, posture, gait, and other midline symptoms, such as speech and facial expression, compared with rigidity, seem to be more closely related to striatal DAT binding. By contrast, neither the severity of parkinsonian rest nor of action tremor is related to the degree of dopaminergic denervation as measured by DAT imaging. Motor symptoms in the clinically less affected body side show a closer correlation with striatal DAT binding than do symptoms occurring in the dominantly affected body side. The correlation of putamen and caudate DAT binding with parkinsonian motor handicap seems to be similar. Although there have been limited comparative studies applying [18F]fluorodopa PET and DAT imaging in the same group of PD patients, available data suggest that putamen [18F]fluorodopa uptake, when compared with striatal DAT binding, may be more closely related to parkinsonian motor handicap. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004144 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004144 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:EE5E852D2FAD10ECDAA841B72FF380AB478A3006
|texte= Correlation of dopamine transporter imaging with parkinsonian motor handicap: How close is it?
}}
| This area was generated with Dilib version V0.6.23. |  |